2021asco涓浗寮洪煶|閭靛織鏁忔暀鎺?orr 81.3%鈥斺€斿崱鐟炲埄鐝犲崟鎶桭uture-乐乐捕鱼2

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  • 2021asco涓浗寮洪煶|閭靛織鏁忔暀鎺?orr 81.3%鈥斺€斿崱鐟炲埄鐝犲崟鎶桭uture-c-plus鐮旂┒寮曢tnbc鍏嶇柅

    鍙戝竷浜?2021-06-10 10:11鏉ユ簮:涓浗鍖诲璁哄潧鎶ヤ粖鏃ヨ偪鐦?

    2021骞寸編鍥戒复搴婅偪鐦ゅ浼氾紙asco锛夊勾浼氫簬褰撳湴鏃堕棿6鏈?鏃8鏃ヤ互绾夸笂浼氳褰㈠紡鐩涘ぇ鍙紑銆備綔涓哄叏鐞冭偪鐦ら鍩熼灞堜竴鎸囩殑瀛︽湳浜ゆ祦鐩涗細锛孉sco骞翠細姹囪仛涓氬唴椤跺皷涓撳瀛﹁€咃紝鑱氱劍鑲跨槫鍓嶆部鏂扮煡锛屾帰璁ㄧ鐮斿垱鏂版垚鏋滐紝鎺ㄥ姩涓村簥瀹炶返闈╂柊锛屽紩棰嗙潃鍏ㄧ悆鑲跨槫璇婄枟浜嬩笟涓嶆柇寮€鎷撳墠琛屻€?/span>

    鐢?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">澶嶆棪澶у闄勫睘鑲跨槫鍖婚櫌閭靛織鏁忔暀鎺?/strong>鐗靛ご鐨勨€?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">娉曠背鏇垮凹鑱斿悎鍗$憺鍒╃彔鍗曟姉 鐧借泲鐧界传鏉夐唶涓€绾挎不鐤楀厤鐤皟鑺傚瀷鏅氭湡涓夐槾鎬?a href='http://www.xuelun.net' target='_blank'>涔宠吅鐧岀殑鈪℃湡涓村簥鐮旂┒鈥濓紙future-c-plus鐮旂┒锛夎劚棰栬€屽嚭锛屾垚鍔熷叆閫夋湰灞婂勾浼氱殑鍙eご鎶ュ憡銆?/span>

    2020骞?鏈堬紝閭靛織鏁忔暀鎺堝洟闃熺殑furure鐮旂┒浜庡浗闄呴《绾у鏈湡鍒娿€婄粏鑳炵爺绌躲€嬶紙cell res.锛夐噸纾呭彂甯冿紝寮€鍚簡涓夐槾鎬?a href='http://www.xuelun.net' target='_blank'>涔宠吅鐧?/u>锛圱nbc锛夌簿鍑嗘不鐤楃殑鏂板ぇ闂ㄣ€傞殢鐫€future鐮旂┒鐨勮繘涓€姝ユ繁鍏ワ紝濡備粖涓浗瀛﹁€呮惡鎵嬩腑鍥藉師鐮旇嵂鐗╄崳鐧?021 asco瀛︽湳鑸炲彴锛屼笉浠呭啀搴﹀桨鏄句簡涓栫晫瀵逛腑鍥藉鏈爺绌跺拰鍘熺爺鑽墿鍝佽川鐨勯珮搴﹀叧娉ㄥ拰涓€鑷磋鍙紝涔熶负tnbc绮惧噯娌荤枟鍐嶆坊鏂拌瘉锛屼娇tnbc鐨勬不鐤楀洶澧冭繋鏉ヤ簡鏂扮殑鏇欏厜銆?/span>

    銆婁腑鍥藉尰瀛?a href='http://www.xuelun520.com' target='_blank'>璁哄潧鎶ャ€嬬壒鍒笓璁?strong style="margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">閭靛織鏁忔暀鎺?/strong>锛岃浠栬в璇荤爺绌惰儗鏅紝姊崇悊鐮旂┒鍐呭锛屽垎浜复搴婃劅鎮燂紝骞舵暣鐞嗚璋堢簿瑕侊紝浠ラ(璇昏€呫€?/span>

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    閭靛織鏁? 鏁欐巿

    澶嶆棪澶у闄勫睘鑲跨槫鍖婚櫌涔宠吅澶栫

    澶嶆棪鐗硅仒鏁欐巿銆侀鎵规暀鑲查儴闀挎睙瀛﹁€呯壒鑱樻暀鎺?nbsp;

    澶嶆棪澶у鑲跨槫鐮旂┒鎵€鎵€闀裤€佷钩鑵虹檶鐮旂┒鎵€鎵€闀?/span>

    澶嶆棪澶у闄勫睘鑲跨槫鍖婚櫌澶у绉戜富浠诲吋涔宠吅澶栫涓讳换

    涓浗鎶楃檶鍗忎細涔宠吅鐧屼笓涓氬鍛樹細鍚嶈獕涓诲

    涓浗鎶楃檶鍗忎細鑲跨槫闈跺悜娌荤枟涓撲笟濮斿憳浼氫富浠诲鍛?/span>

    涓崕鍖诲浼氳偪鐦ゅ鍒嗕細鍓富浠诲鍛?nbsp;

    涓崕鍖诲浼氳偪鐦ゅ鍒嗕細涔宠吅瀛︾粍涓讳换濮斿憳

    涓婃捣甯傛姉鐧屽崗浼氫钩鑵虹檶涓撲笟濮斿憳浼氬悕瑾変富浠诲鍛?/span>

    涓婃捣甯傚尰瀛︿細鑲跨槫涓撶濮斿憳浼氫富浠诲鍛?/span>

    绗叓灞婁簹娲蹭钩鑵虹檶鍗忎細涓诲腑

    st.gallen涔宠吅鐧屽ぇ浼氫笓瀹跺洟鎴愬憳


    鐮ョ牶鎺㈢储鍗佷綑杞斤紝

    瀹炵幇tnbc璇婄枟鎸佺画绐佺牬


    q1锛?/strong>
    鎮ㄧ壍澶寸殑future-c-plus鐮旂┒鎴愬姛鍏ラ€?021 asco骞翠細锛岀爺绌剁殑鐤楁晥鏁版嵁鏄剧ず锛屾硶绫虫浛灏艰仈鍚堝崱鐟炲埄鐝犲崟鎶?鐧借泲鐧界传鏉夐唶涓€绾挎不鐤桾nbc鐨勫瑙傜紦瑙g巼锛圤rr锛夐珮杈?1.3%锛岄珮灞呯洰鍓峊nbc涓€绾挎不鐤楁柟妗堟棣栵紱鍚屾椂锛岃鑱斿悎鏂规9涓湀pfs鐜囪揪60.2%锛?0涓湀pfs鐜囪揪53.5%锛岀爺绌舵暟鎹尟濂嬩汉蹇冦€傝鎮ㄤ粙缁嶄竴涓嬪紑灞旻uture-c-plus鐮旂┒鐨勮儗鏅€?/span>

    閭靛織鏁忔暀鎺?/strong>锛?/span>浼楁墍鍛ㄧ煡锛屼笌鍏朵粬涔宠吅鐧屼簹鍨嬬浉姣旓紝tnbc鏃╂湡澶嶅彂椋庨櫓楂樸€傜敱浜庣己灏戞縺绱犲彈浣擄紙hr锛夈€佷汉琛ㄧ毊鐢熼暱鍥犲瓙鍙椾綋2锛圚er2锛夌瓑鐗瑰紓鎬ф不鐤楅澏鐐癸紝鐩墠tnbc鐨勮緟鍔╂不鐤楁柟闈紝鏃犺鏄編鍥藉浗绔嬬患鍚堢檶鐥囩綉缁滐紙nccn锛夋寚鍗椼€丼t. gallen浼氳涓撳鍏辫瘑杩樻槸鎴戝浗鐨勬寚鍗楀叡璇嗭紝鍧囦互鍖栫枟涓轰富銆傜劧鑰屽湪涓村簥瀹炶返涓紝璁稿tnbc鎮h€呭湪鎺ュ彈鎵嬫湳娌荤枟鍚?~2骞村嵆鍑虹幇澶嶅彂锛屼笖澶嶅彂浠ュ悗鍐嶆帴鍙楀寲鐤楃殑鐤楁晥寰€寰€寰堝樊銆備负浜嗚в鍐砊nbc鐨勪复搴婃不鐤楀洶澧冿紝鎴戜滑鐮旂┒鍥㈤槦鍘嗘椂杩?0骞达紝寮€灞曚簡涓€绯诲垪鎺㈢储涓庣爺绌跺伐浣溿€?/span>

    棣栧厛锛屼负浜嗘洿鍏ㄩ潰銆佹洿娣卞叆璁よ瘑tnbc鐨勬湰璐紝瀵绘壘绮惧噯娌荤枟鐨勭獊鐮村彛锛屾垜浠爺绌跺洟闃熷紑灞曚簡future鐮旂┒锛屽叏闈㈠垎鏋愪簡465渚嬪師鍙戞€nbc鎮h€呯殑涓村簥銆佸熀鍥犵粍鍜岃〃杈捐氨鏁版嵁锛屽彂鐜癟nbc鏄竴绉嶅叿鏈夐珮搴﹀紓璐ㄦ€х殑鐤剧梾銆傚悓鏃讹紝鏍规嵁鍩哄洜缁勮〃杈捐氨鐨勪笉鍚岋紝鎴戜滑寤虹珛浜員nbc鈥滃鏃﹀垎鍨嬧€濇爣鍑嗭紝灏員nbc鍒嗕负鍥涗釜涓嶅悓鐨勪簹鍨嬶細鑵旈潰闆勬縺绱犲彈浣撳瀷锛圠ar锛夈€佸厤鐤皟鑺傚瀷锛圛m锛夈€佸熀搴曟牱鍏嶇柅鎶戝埗鍨嬶紙is锛夈€侀棿璐ㄥ瀷锛圡es锛夈€傚悇浜氬瀷鍧囨湁鐩稿簲鐗瑰畾鐨勪竴浜涙不鐤楅澏鐐广€傝繖椤笷uture鐮旂┒鐨勬垚鏋滀簬2019骞村彂甯冧簬銆婄粏鑳炵爺绌躲€嬶紙cell res.锛変笂锛屼负tnbc鐨勭簿鍑嗚瘖鐤楁彁渚涗簡鏂版€濊矾銆?/span>

    涓轰簡杩涗竴姝ユ帹鍔‵uture鐮旂┒鎴愭灉鐨勪复搴婂簲鐢紝鎴戜滑鎼烘墜鎭掔憺鍖昏嵂寮€灞曚簡鏇村鎺㈢储銆傚湪tnbc鈥滃鏃﹀垎鍨嬧€濈殑鎸囧涓嬶紝鎴戜滑灏嗙粡澶氱嚎娌荤枟澶辫触鍚庣殑69渚婽nbc鎮h€呭垎涓?涓不鐤楄噦锛圓鑷倊g鑷傦級锛屽簲鐢ㄤ互鎭掔憺鍖昏嵂鑷富鐮斿彂鐨勫绉嶅垱鏂版姉鑲跨槫鑽墿涓轰唬琛ㄧ殑涓板瘜娌荤枟鎵嬫锛屽鍚勪釜鑷傜殑鎮h€呰繘琛屼笉鍚屾柟妗堢殑绮惧噯娌荤枟銆傜粨鏋滄樉绀猴紝鎬讳汉缇ょ殑orr鎺ヨ繎30%锛屽叾涓紝im鍨婽nbc鎮h€咃紙c鑷傦級鎺ュ彈鍗$憺鍒╃彔鍗曟姉 鐧借泲鐧界传鏉夐唶娌荤枟鐨凮rr楂樿揪52%锛屽惎鍙戜簡鍚庣画鎺㈢储鐨勬柊鎬濊矾銆?/span>

    future鐮旂┒c鑷傚彲瑙傜殑orr鏁版嵁灞曠幇鍑轰簡鍏嶇柅娌荤枟鍦ㄥ绾挎不鐤楀け璐ョ殑im鍨婽nbc鎮h€呬腑鐨勬樉钁楃枟鏁堬紝涓轰簡鎺㈢储鍏嶇柅娌荤枟鍦ㄨ繖绫绘偅鑰呬竴绾挎不鐤椾腑鐨勭枟鏁堬紝鎴戜滑鍦–鑷傚崱鐟炲埄鐝犲崟鎶?鐧借泲鐧界传鏉夐唶鏂规鐨勫熀纭€涓婏紝鍒涙柊鎬ц仈鍚堟姉琛€绠$敓鎴愰澏鍚戣嵂鐗╂硶绫虫浛灏硷紝绾冲叆48渚嬶紙鍏朵腑鍙瘎浼?6渚嬶級鍏嶇柅璋冭妭鎬ф櫄鏈烼nbc鎮h€咃紝寮€灞曚簡杩欓」future-c-plus鐮旂┒锛屾帰绱笁鑽仈鍚堟柟妗堜竴绾挎不鐤桰m鍨嬫櫄鏈烼nbc鐨勭枟鏁堛€傜粨鏋滄樉绀猴紝娉曠背鏇垮凹鑱斿悎鍗$憺鍒╃彔鍗曟姉 鐧借泲鐧界传鏉夐唶娌荤枟鐨勫瑙傜紦瑙g巼锛圤rr锛夐珮杈?1.3%锛屽姝ゆ儕鑹崇殑鐤楁晥鏁版嵁闈炲父鎸浜哄績銆?/span>


    鍏嶇柅娌荤枟鍓嶆櫙鍙緟锛?/strong>

    tki闈跺悜鍔犳寔鍔╁姏鏇翠紭鐤楁晥

    q2锛?/strong>浠嶧uture鐮旂┒鐨凜鑷傚埌future-c-plus鐮旂┒锛屽墠鐬绘€х爺绌朵腑灞曠幇鍑哄厤鐤仈鍚堟姉琛€绠$敓鎴愶紙 鍖栫枟锛夋柟妗堢殑鐤楁晥浠や汉娆e枩銆傛偍璁や负鍝簺tnbc鎮h€呮洿鑳戒粠鍏嶇柅娌荤枟涓幏鐩婏紵鍩轰簬future绯诲垪鐮旂┒锛屾硶绫虫浛灏艰仈鍚堝崱鐟炲埄鐝犲崟鎶?鐧借泲鐧界传鏉夐唶鐨勪笁鑽仈鍚堟柟妗堝湪tnbc娌荤枟涓彇寰椾紭瓒婄枟鏁堢殑鏈哄埗鏈夊摢浜涳紵

    閭靛織鏁忔暀鎺?/strong>锛?/span>鑲跨槫鐨勫厤鐤井鐜瀵逛簬鍏嶇柅娌荤枟鐤楁晥鍏锋湁鏄捐憲褰卞搷锛屾垜浠爺绌跺洟闃熼€氳繃鎺㈢储鍜屽垎鏋愶紝浜?019骞村湪銆婁复搴婄檶鐥囩爺绌躲€嬶紙clin cancer res锛夊彂琛ㄧ殑鐮旂┒灏員nbc鎮h€呮寜鐓у厤鐤姸鎬佸垎涓?涓笉鍚岀殑绛夌骇锛屽嵆鍐疯偪鐦わ紝浠ュ強涓害鍜屾瀬搴﹀厤鐤皟鑺傚瀷銆?/span>

    鍦‵uture-c-plus鐮旂┒涓紝鎴戜滑灏咰d8缁嗚優鐨勫厤鐤粍缁囧寲瀛︼紙ihc锛夎瘎鍒嗗ぇ浜?0%浣滀负im鍨嬬殑cut-off鍊硷紝im鍨婽nbc鎮h€呭崰tnbc鎬讳綋鐨?0%宸﹀彸銆傜敱姝ゅ彲瑙侊紝鑳戒粠鍏嶇柅娌荤枟涓幏鐩婄殑tnbc鎮h€呯兢浣撴槸闈炲父骞块様鐨勩€?/span>

    鍚屾椂锛屽湪future鐮旂┒鍏嶇柅娌荤枟 鍖栫枟鐨勫熀纭€涓婏紝future-c-plus鐮旂┒鍔犲叆浜嗗皬鍒嗗瓙閰皑閰告縺閰舵姂鍒跺墏锛圱ki锛夋硶绫虫浛灏笺€傝繖鏍风殑涓夎嵂鑱斿悎鏂规鍦ㄧ粨鑲犵檶绛夌槫绉嶇殑娌荤枟棰嗗煙宸叉湁搴旂敤锛涘悓鏃讹紝鍔ㄧ墿瀹為獙宸茬粡璇佸疄鎶楄绠$敓鎴愯嵂鐗╄兘澶熷鍔犲厤鐤粏鑳炵殑娴告鼎锛岃繖灏卞惎鍙戞垜浠€氳繃鍏嶇柅娌荤枟鑱斿悎鎶楄绠$敓鎴愯嵂鐗╋紝浣库€滃喎鑲跨槫鈥濊浆鍙樹负鈥滅儹鑲跨槫鈥濓紝澧炲己鑲跨槫鐨勫厤鐤師鎬э紝浠庤€屽垏瀹炴彁鍗囧厤鐤不鐤楃殑鐤楁晥銆侳uture-c-plus鐮旂┒鐨勭粨鏋滀篃璇佸疄浜嗕笁鑽仈鍚堟柟妗堢殑浼樿秺鐤楁晥銆傛澶栵紝鎴戜滑涔熷湪绉瀬寮€灞曞姩鐗╁疄楠岋紝鍘绘繁鍏ユ帰绱笁鑽仈鍚堢殑鏇村鑾风泭鏈哄埗銆?/span>


    闃电嚎鍓嶇щ鏈潵宸叉潵锛?/strong>

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    -浠ヤ笂-


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