銆愮鑳朵箟涔炽€戜粈涔堟槸闈跺悜娌荤枟锛熷張鏈夊摢浜涢澏鍚戣嵂鐗╋紵-乐乐捕鱼2

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  • 銆愮鑳朵箟涔炽€戜粈涔堟槸闈跺悜娌荤枟锛熷張鏈夊摢浜涢澏鍚戣嵂鐗╋紵

    鍙戝竷浜?2017-01-04 09:33鏉ユ簮:纭呰兌涔変钩

     

          鎵€璋?ldquo;闈跺悜娌荤枟”锛岀畝鍗曡€岃█锛屽氨鏄鐧岀粏鑳炶繘琛岀簿纭墦鍑伙紝瀵规満浣撴甯哥粏鑳炵殑褰卞搷鐩稿杈冨皬銆?/span>

     

          灏卞儚鏃ュ父鐢熸椿涓鍒扮殑鏌愪簺妤兼埧杩涜鎷嗛櫎锛屽畾鍚戠垎鐮翠竴鏍凤紝闈跺悜鑽墿鍙互鐩存帴鎴栭棿鎺ヤ綔鐢ㄥ埌涔宠吅鐧岀粏鑳炰笂锛屼娇缁嗚優涓嶈兘鍐嶇箒娈栥€佸瓨娲伙紝璧峰埌鏉€浼?a href='http://www.xuelun.net' target='_blank'>涔宠吅鐧岀粏鑳炵殑浣滅敤銆?/span>

     

          杩戝勾鏉ワ紝闅忕潃鍒嗗瓙鐢熺墿瀛︽妧鏈殑杩涙锛屼汉浠粠鍒嗗瓙姘村钩瀵硅偪鐦ゅ彂鐢熴€佸彂灞曞強渚佃鏈哄埗鐨勭爺绌惰秺鏉ヨ秺娣卞叆锛屽彂鐜板湪涔宠吅鐧?/u>涓瓨鍦ㄥ涓俊鍙烽€氳矾鐨勫紓甯搞€?/span>

     

          杩欎簺淇″彿閫氳矾鍙互鎶婁竴浜涙湁鍒╀簬鑲跨槫澧炴畺銆佽浆绉荤殑淇″彿浼犻€掔粰鐧岀粏鑳烇紝淇冭繘鑲跨槫鐨勫彂灞曞拰杞щ銆?/span>

     

          鑰岄澏鍚戞不鐤楋紝鎵€杩芥眰鐨勫氨鏄湪閫氳矾涓紝杩涜瀹氬悜鎷︽埅锛岄樆姝㈡湁鍒╀簬鑲跨槫澧炴畺鍜岃繘涓€姝ヨ浆绉荤殑鍙戠敓銆傞偅涔堬紝闈跺悜鑽墿閮芥湁鍝簺鍛紵

     

     

     

     

          鎺掑悕绗竴鐨勶紝褰撶劧闈炶但璧涙眬鑾睘銆?/span>

     

          浼楁墍鍛ㄧ煡锛岃但璧涙眬鍦ㄩ拡瀵逛汉琛ㄧ毊鐢熼暱鍥犲瓙鍙椾綋锛圚er2锛夌殑涔宠吅鐧岄澏鍚戞不鐤椾腑鏁堟灉闈炲父鏄庢樉銆?/span>

     

          her鍙椾綋琛ㄨ揪鍦ㄧ粏鑳炶〃闈紝閫氳繃鎰熷彈澶栫晫鐨勪俊鍙峰埡婵€灏嗙敓闀夸俊鍙蜂紶閫掑埌缁嗚優鍐呴儴锛屼粠鑰屽埡婵€缁嗚優鐨勫娈栵紝鍦ㄧ浉褰撲竴閮ㄥ垎鐨勪钩鑵虹檶缁嗚優涓璈er2鏄繃琛ㄨ揪鐨勶紝杩欏鑷翠簡鐧岀粏鑳炵敓闀跨殑澶辨帶銆?/span>

     

          鏃╁湪1998骞达紝璧禌姹€灏辫fda鎵瑰噯涓婂競锛屾槸闈跺悜娌荤枟鑽墿涔嬩竴锛岀洰鍓嶅凡缁忔槸娌荤枟her2闃虫€т钩鑵虹檶鐨勯粍閲戞爣鍑嗐€傝但璧涙眬杩戝嚑骞寸殑骞撮攢鍞涓€鐩寸淮鎸佸湪60浜跨編鍏冧互涓婏紝閴翠簬缇庡浗涓撳埄灏嗕簬2019骞村埌鏈燂紝灞婃椂閿€鍞灏嗗彈鍒颁豢鍒惰嵂鐗╄緝澶у奖鍝嶏紝棰勬祴2017骞撮攢鍞63.9浜跨編鍏冿紝2021骞撮攢鍞52.8浜跨編鍏冦€?/span>

     

     

     

          浣滀负涓€绉嶅彛鏈嶆€ф姉cdk锛堢粏鑳炲懆鏈熻泲鐧戒緷璧栨€ф縺閰讹級鎶戝埗鍓傦紝ibrance鏄叏鐞冮涓鎵瑰噯涓婂競鐨凜dk4/8鎶戝埗鍓傘€?/span>

     

          cdk鏄粏鑳炲垎瑁傚娈栬繃绋嬩腑涓嶅彲缂哄皯鐨勫洜瀛愶紝鍦ㄧ檶缁嗚優涓挨涓烘椿璺冿紝鍥犳cdk涔熸槸鎶楄偪鐦よ嵂鐗╁紑鍙戠殑涓€涓儹闂ㄩ澏鐐广€備笉杩囷紝涓庤但璧涙眬鏃╂棭鑾锋壒鎶曞叆涓村簥浣跨敤鐩告瘮锛岀洿鍒?015骞?鏈堬紝缇庡浗鐨勯鍝佽嵂鍝佺洃绠″眬锛團da锛夋墠鎵瑰噯ibrance鐢ㄤ簬涓€绾挎不鐤?er /her2- 缁濈粡鍚庢櫄鏈熶钩鑵虹檶锛?016骞?鏈堬紝ibrance鐢ㄤ簬浜岀嚎娌荤枟娌荤枟er /her2-缁濈粡鍚庢櫄鏈熶钩鑵虹檶銆?/span>

     

          濡傛灉璇磋但璧涙眬鏄疕er2闃虫€т钩鑵虹檶鐨勯粍閲戞爣鍑嗙殑璇濓紝閭d箞ibrance姝e湪鎴愪负her2鏅氭湡涔宠吅鐧岀殑娌荤枟鑽墿鏍囨潌銆?/span>

     

          鐩墠锛孖brance杩樻湁鏁颁釜閫傚簲鐥囩殑涓村簥鐮旂┒姝e湪杩涜涓紝鍖呮嫭楂橀闄╂棭鏈熶钩鑵虹檶浠ュ強鏃╂湡涔宠吅鐧岀殑杈呭姪娌荤枟锛屼竴鏃︾爺绌舵垚鍔燂紝灏嗘墿澶brance鐨勯€傜敤浜虹兢銆?/span>

     

          perjeta锛堝笗濡ョ彔鍗曟姉锛夈€傝繖鏄疕er浜岃仛鍖栨姂鍒跺墏涓殑棣栧垱鏂拌嵂锛岃兘閫氳繃鎶戝埗her2浜岃仛鍖栵紝闃绘鑲跨槫鐨勭敓闀垮拰澧炴畺淇″彿鐨勪紶瀵笺€?/span>

     

          姝よ嵂2012骞村湪缇庡浗涓婂競锛屽畠鐩墠琚壒鍑嗙敤浜庤仈鍚堣但璧涙眬鍜岀传鏉夎悳鐢ㄤ簬娌荤枟鎵╂暎鎬er2闃虫€т钩鑵虹檶锛?/span>

     

          鍚屾椂浣滀负杈呭姪娌荤枟鑽墿鐢ㄤ簬her-2闃虫€ф棭鏈熶钩鑵虹檶鐨勬不鐤楋紝鐩墠杩樻湁3涓狪ii鏈熶复搴婄爺绌舵鍦ㄨ繘琛屽綋涓紝鍏堕€傚簲鐥囧皢杩涗竴姝ユ墿澶с€?/span>

     

          perjeta鐨勬壒鍑嗗湪鐩稿綋绋嬪害涓婂皢缂撹вherceptin涓撳埄鍒版湡瀵圭綏姘忕殑褰卞搷銆備笉杩囷紝璇ヨ嵂鐩墠鍦ㄥ浗鍐呰繕娌℃湁涓婂競銆?/span>

     

     

           kadcyla銆傝繖鏄竴绉嶆姉浣撳伓鑱旇嵂鐗┿€?/span>

     

          鎶椾綋鍋惰仈鑽墿鏄繎骞存潵鍙戝睍璧锋潵鐨勪竴绉嶆柊鍨嬫姉鑲跨槫鑽墿锛岀悊璁轰笂瀹冨悓鏃跺叿鏈夋姉浣撶壒寮傛€ч珮鍜岀粏鑳炴瘨鎬ц嵂鐗╁鐧岀粏鑳炴潃浼よ兘鍔涘己鐨勪紭鐐癸紝kadcyla鏄绫昏嵂鐗╀腑鐨勯鍒涙柊鑽€?/span>

     

          鍦ㄤ竴娆′复搴婄爺绌朵腑锛屽彂鐜板璧禌姹€浜х敓鎶楁€х殑鎮f湁鏅氭湡her2闃虫€т钩鑵虹檶鐨勭梾浜轰腑锛屾湇鐢↘adcyla 姣旇仈鍚堟湇鐢ㄥ叾浠栬嵂鐗╁彲浠ユ彁楂樻€讳綋鐢熷瓨鐜?.8涓湀銆?/span>

     

          姝f槸鍩轰簬杩欎釜涓村簥鐮旂┒锛?013骞?鏈堢編鍥界殑fda鎵瑰噯kadcyla涓婂競锛岀敤浜庝簩绾挎不鐤楁帴鍙楄繃璧禌姹€鎴栬€匬erjeta娌荤枟鐨勪钩鑵虹檶鎮h€呮垨鑰呭鍙戞偅鑰呫€?/span>

     

          姝よ嵂姣旇但璧涙眬鏇村己澶э紝涔熸洿璐碉紝浠锋牸鏄悗鑰呯殑涓ゅ€嶏紝瀹冧篃鏄湭鏉ュ簲瀵硅但璧涙眬涓撳埄鍒版湡鍚庣殑鐑棬闈跺悜娌荤枟鑽墿涔嬩竴銆?/span>

     

     

     

          afinitor锛堜緷缁磋帿鍙革級銆傛鑽墿鐨勯€傚簲鐥囨瘮杈冨箍娉涳紝闄や簡鐢ㄤ簬娌荤枟澶氱鐧岀棁锛屽悓鏃惰繕鐢ㄤ簬鍣ㄥ畼绉绘鍚庣殑鍏嶇柅鎺掓枼鍙嶅簲銆?011骞翠竴椤笽ii鏈熶复搴婄爺绌惰〃鏄庯紝渚濈淮鑾徃鍚屽寲鐤楄嵂鐗?ldquo;渚濊タ缇庡潶”鑱斿悎娌荤枟鏅氭湡涔宠吅鐧岋紝姣斿崟鐙娇鐢?ldquo;渚濊タ缇庡潶”鍙互鏄捐憲寤堕暱鐥呬汉鐨勬棤杩涘睍鐢熷瓨鏈熴€?/span>

     

          姝f槸鍩轰簬姝ら」鐮旂┒锛?012骞?鏈堬紝fda鎵瑰噯鐢ㄤ簬鍚?ldquo;渚濊タ缇庡潶”鑱斿悎娌荤枟缁濈粡鍚嶩r /her2-鐨勪钩鑵虹檶娌荤枟銆?br />
          鍐呭鏉ヨ嚜锛氬井淇″叕浼楀彿锛歴hxljkw (闆鸡灞?锛屾兂鑾峰緱鏇村瀹炵敤骞茶揣锛岃鍏虫敞闆鸡纭呰兌瀹樼綉锛侊紒

     

    鏍囩(tag):
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