瀵归潰涔崇檶锛屼笁娆炬姂鍒跺墏鏉ヨ-乐乐捕鱼2

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  • 瀵归潰涔崇檶锛屼笁娆炬姂鍒跺墏鏉ヨ

    鍙戝竷浜?2018-03-26 09:38鏉ユ簮:纭呰兌涔変钩
          浼楁墍鍛ㄧ煡锛岀敱浜?a href='http://www.xuelun.net' target='_blank'>涔宠吅鐧屾槸涓€绉嶆縺绱犱緷璧栨€ц偪鐦わ紝鐧岀粏鑳炵殑鐢熼暱鍙椾綋鍐呭绉嶆縺绱犵殑璋冩帶銆傚叾涓紝闆屾縺绱犲湪澶ч儴鍒?a href='http://www.xuelun.net' target='_blank'>涔宠吅鐧岀殑鍙戠敓鍙戝睍涓捣鐫€鑷冲叧閲嶈鐨勪綔鐢ㄣ€?br />
           鑰屽唴鍒嗘硨娌荤枟鑳介€氳繃闄嶄綆浣撳唴闆屾縺绱犳按骞虫垨鎶戝埗闆屾縺绱犵殑浣滅敤锛岃揪鍒版姂鍒惰偪鐦ょ粏鑳炵殑鐢熼暱銆?br />
           鍝簺鐥呬汉閫傚悎浣滃唴鍒嗘硨娌荤枟锛屼复搴婃槸閫氳繃妫€娴嬬梾浜?a href='http://www.xuelun.net' target='_blank'>涔宠吅鐧?/u>缁嗚優鐨勯泴婵€绱犲彈浣?er)鍜屽瓡婵€绱犲彈浣?pr)锛屽涓よ€呯殕闃虫€ф垨浠讳竴涓洪槼鎬э紝鐩墠璁や负锛屼笉璁哄勾榫勩€佹湀缁忕姸鍐碉紝鏈悗閮藉簲璇ユ帴鍙楀唴鍒嗘硨娌荤枟銆?br />
           cdk4/6鎶戝埗鍓傛槸浠€涔堬紵

           缁嗚優鍛ㄦ湡铔嬬櫧渚濊禆鎬ф縺閰讹紙cdk锛夊湪璋冭妭缁嗚優鍛ㄦ湡杩涚▼涓彂鎸ョ潃鍏抽敭浣滅敤銆?br />
           缁嗚優鍛ㄦ湡澶辨帶鏄檶鐥囩殑涓€涓爣蹇楁€х壒寰侊紝鑰孋dk4/6鏄粏鑳炲懆鏈熺殑鍏抽敭璋冭妭鍥犲瓙锛屽湪璁稿鐧岀棁涓紝cdk4/6杩囧害娲昏穬瀵艰嚧缁嗚優澧炴畺澶辨帶銆傚洜姝わ紝杩戝勾鏉ワ紝闈跺悜鎶戝埗cdk4/6閫氳矾宸叉垚涓烘姉鐧屾柊鑽爺鍙戠殑涓€澶х儹鐐广€?br />
           鍏跺疄锛岄拡瀵逛钩鑵虹檶鐨勪复搴婄爺绌朵竴鐩村湪杩涜锛屽浜庢縺绱犲彈浣撻槼鎬х殑涔宠吅鐧屾偅鑰咃紝涓昏娌荤枟鎵嬫涓哄唴鍒嗘硨娌荤枟銆?br />
           浣嗘槸cdk4/6鐨勫紓甯告縺娲讳細閫犳垚鍐呭垎娉屾不鐤楄€愯嵂鐨勫彂鐢燂紝濡傝兘闃绘柇cdk4/6寮傚父婵€娲伙紝鍙湁鏁堟帶鍒惰偪鐦ょ敓闀裤€?br />
           2017骞?鏈堬紝abemaciclib鑾锋壒鐢ㄤ簬鐢ㄤ簬hr闃虫€с€丠er2闃存€х殑鏅氭湡鎴栧鍙戜钩鑵虹檶鐨勬不鐤椼€?br />
           abemaciclib鏄編鍥紽da鎵瑰噯鐨勭涓夋cdk4/6鎶戝埗鍓傦紝涔熸槸鍞竴涓€娆捐幏鎵逛綔涓哄崟鐙枟娉曚娇鐢ㄧ殑cdk4/6鎶戝埗鍓傘€?br />
           涓昏鏂规硶

           鍦ㄨ瘯楠屼腑锛?93渚嬪眬閮ㄥ尯鍩熷鍙戞垨杞щ鎬т钩鑵虹檶缁濈粡鍚庡コ鎬т互2锛?鐨勬瘮渚嬭闅忔満鍒嗛厤鑷?50 mg锛屾瘡鏃ヤ袱娆bemaciclib鎴栧畨鎱板墏銆?br />
           鎵€鏈夋偅鑰呮瘡澶╀篃鎺ュ彈1mg闃块偅鏇插攽鎴?.5mg鏉ユ洸鍞戙€傝櫧鐒跺厑璁歌緟鍔╁唴鍒嗘硨娌荤枟锛屼絾鎮h€呮棦寰€鏈帴鍙楄繃鎸芥晳娌荤枟銆備腑浣嶉殢璁挎椂闂翠负17.8涓湀銆?br />
           涓ょ粍鎮h€呯殑涓綅骞撮緞涓?3宀侊紝绾?0%鎮h€呭湪鍩虹嚎鏃舵湁鍙祴閲忕殑鐤剧梾銆傚ぇ澶氭暟鎮h€呮湁杞щ鎬у鍙戯紙55.5%-60%锛夛紝灏嗚繎40%鐨勬偅鑰呮湁鏂板彂杞щ鎬х柧鐥呫€?br />
           澶х害54%鐨勬偅鑰呮偅鏈夊唴鑴忕柧鐥咃紝杩?2%鎮f湁楠ㄩ鐤剧梾銆傚皢杩戜竴鍗婄殑鎮h€呮帴鍙椾簡鏂拌緟鍔╂垨杈呭姪鍐呭垎娉屾不鐤椼€?br />
           缁撴灉鏄剧ず锛宎bemaciclib缁勪腑锛孋dk4/6鎶戝埗鍓傜殑瀹㈣缂撹в鐜囷紙orr锛変负55.4%锛屽鐓х粍涓?0.2%銆傚綋鐒讹紝abemaciclib涔熸湁鐩稿叧鍓綔鐢ㄣ€?br />
           鏈夊叧鐨勫父瑙佺殑涓嶈壇浜嬩欢灏辨槸鑵规郴锛屽彂鐢熷湪鐢–dk4 / 6鎶戝埗鍓傛不鐤楃殑鎮h€呬腑鐨勬瘮渚嬩负81.3%锛岃€屽鐓х粍涓殑姣斾緥涓?9.8%銆?br />
           闄よ吂娉诲锛屼腑鎬х矑缁嗚優鍑忓皯鐥囦篃寰堝父瑙併€傚湪鎺ュ彈abemaciclib娌荤枟鐨勬偅鑰呬腑锛屽彂鐢熻繖涓€鎯呭喌鐨勬瘮渚嬩负41.3%锛屽鐓х粍涓?.9%銆俛bemaciclib缁勪粎1鍚嶆偅鑰呭嚭鐜板彂鐑€т腑鎬х矑缁嗚優鍑忓皯鐥囥€?br />
           “杩欓」瀹℃壒鏄竴涓噸瑕佺殑閲岀▼纰戯紝瀹冭〃鏄巃bemaciclib鍔犺姵棣欏寲閰舵姂鍒跺墏鍙樉鐫€鍑忓皯hr 锛孒er2-杞щ鎬т钩鑵虹檶濂虫€х殑鑲跨槫澶у皬锛屽欢缂撶柧鐥呰繘灞曘€?rdquo;寰峰厠钀ㄦ柉宸炶礉鍏嬪ぇ瀛﹀尰瀛︿腑蹇冧钩鑵虹檶鐮旂┒璁″垝涓讳换涔斾紛鏂紙joyce o'shaughnessy锛夊崥澹湪涓€浠藉0鏄庝腑琛ㄧず銆?br />
           杩樻湁2娆炬姂鍒跺墏

           鎴鍒扮洰鍓嶏紝涔宠吅鐧岄鍩熶竴鍏辨湁3涓狢dk4/6鎶戝埗鍓傝鎵瑰噯涓婂競銆傞櫎浜嗘渶鏂拌鎵瑰噯鐨凙bemaciclib锛屽叾浣欎袱鑰呭垎鍒槸palbociclib鍜孯ibociclib銆?br />
           palbociclib

           palbociclib鏄竴绉嶅疄楠屾€с€佸彛鏈嶃€侀澏鍚戞€у埗鍓傦紝鑳藉閫夋嫨鎬ф姂鍒禖dk4/6閰剁殑娲绘€ф潵闈跺悜鑲跨槫缁嗚優骞舵仮澶嶇粏鑳炲懆鏈熸帶鍒讹紝鍚屾椂闃绘柇鑲跨槫缁嗚優澧炴畺锛?br />
           瀹冧簬2013骞?鏈堣幏寰椾簡fda鍏充簬鍏舵不鐤楁櫄鏈熸垨杞щ鎬r /her2-涔宠吅鐧岀殑绐佺牬鎬х枟娉曡瀹氾紝2015骞?鏈堟洿鑾锋壒鎴愪负涔宠吅鐧屼竴绾挎不鐤楅澏鍚戠敤鑽紝鎴愪负鍏ㄧ悆棣栦釜涓婂競鐨凜dk4/6鎶戝埗鍓傘€?br />
           鐮旂┒鏁版嵁琛ㄦ槑锛屽湪鏃㈠線鏈帴鍙楄繃绯荤粺娌荤枟浠ユ帶鍒舵櫄鏈熺梾鎯呯殑闆屾縺绱犲彈浣撻槼鎬с€佷汉绫昏〃鐨敓闀垮洜瀛愬彈浣?闃存€э紙er /her2-锛夌殑缁濈粡鍚庢櫄鏈熶钩鑵虹檶鎮h€呯殑娌荤枟涓紝palbociclib letrozole锛堣姵棣欏寲閰舵姂鍒跺墏鏉ユ洸鍞戯級鐨勮仈鍚堢敤鑽笌鏍囧噯鐤楁硶letrozole鍗曚竴鐢ㄨ嵂鐩告瘮锛岀柧鐥呮棤杩涘睍鐢熷瓨鏈燂紙pfs锛夊彇寰椾簡缁熻瀛︽剰涔夌殑鏄捐憲寤堕暱锛?0.2涓湀vs 10.2涓湀锛夛紝鑰屼笖鍏锋湁鏇村ソ鐨勮€愬彈鎬у拰瀹夊叏鎬э紝杈惧埌浜嗙爺绌剁殑涓昏缁堢偣锛屼负涔宠吅鐧岀殑涓村簥娌荤枟甯︽潵浜嗛噸澶ц繘姝ャ€?br />
           palbociclib鐨勬帹鑽愬墏閲忎负125姣厠姣忔棩鍙f湇涓€娆★紝杩炵画鏈嶇敤21澶╋紝鍋滆嵂7澶╋紝鎬诲叡28澶╀竴鍛ㄦ湡銆?br />
           ribociclib

           2017骞?鏈?4鏃ワ紝fda鎵瑰噯浜哛ibocilib涓庤姵棣欓叾鎶戝埗鍓傝仈鐢紝鐢ㄤ簬娌荤枟hr /her2-鐨勭粷缁忓悗涔宠吅鐧屾偅鑰呫€?br />
           ribociclib鍦?016骞?鏈堢殑涓村簥璇曢獙鍥犱负鐤楁晥鏄捐憲琚彁鍓嶇粓姝€備笌鏉ユ洸鍞戯紙letrozole锛夌浉姣旓紝ribociclib 鏉ユ洸鍞戣仈鍚堟不鐤椾娇鐤剧梾杩涘睍鎴栨浜¢闄╂樉钁楅檷浣?4%銆?br />
           ribociclib鐨勫父鐢ㄥ墏閲忎负姣忔鍙f湇600mg锛?00mg鐗囧墏3鐗囷級锛屾瘡鏃ヤ竴娆★紝鏈嶇敤3鍛紝鍋?鍛ㄣ€?ribociclib鍙仈鍚堜换浣?鍛ㄨ姵棣欓叾鎶戝埗鍓傛不鐤楋紝鍖呮嫭鏉ユ洸鍞戙€傚唴瀹规潵鑷細寰俊鍏紬鍙凤細shxljkw (闆鸡灞?锛屾兂鑾峰緱鏇村瀹炵敤骞茶揣锛岃鍏虫敞闆鸡纭呰兌瀹樼綉锛侊紒
    鏍囩(tag):
    ------鍒嗛殧绾?---------------------------
    ------鍒嗛殧绾?---------------------------